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Leishmaniasis Vaccine
Quillaja saponaria sapogenins protect against visceral leishmaniasis
September 8th, 2004
Aldehyde-containing Quillaja saponaria sapogenins protected against murine visceral leishmaniasis. "The presence of aldehyde groups at C-23 and C-24 of the triterpene aglycon moiety was disclosed in 1H NMR spectra of both the Riedel de Haen saponin (R) (delta 9.336) and Quillaja saponaria QuilA saponin (delta 9.348). The sign of the C-28 acylated linked moiety (delta 176) was present in both saponins, while the delta 171 at C-28 (carboxy group) corresponding to the deacylated saponin, was only detected in the QuilA preparation, indicating 50% of hydrolysis of the ester moiety, probably due to the storage in aqueous solution," researchers in...
Source: Vaccine Weekly (2004-09-08)
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