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Lymphoma Vaccine
Novel diffuse large B-cell lymphoma cancer testis antigen identified
September 8th, 2004
Scientists have identified a novel diffuse large B-cell lymphoma-associated cancer testis antigen encoding a PAS domain protein. According to published research from England, "Here we report that the OX-TES-1 SEREX antigen, which showed immunological reactivity with serum from 4 out of 10 diffuse large B-cell lymphoma (DLBCL) patients, is encoded by a novel gene, PAS domain containing 1 (PASD1). PASD1_v1 cDNA encodes a 639 amino-acid (aa) protein product, while an alternatively spliced variant (PASD1_v2), lacking intron 14, encodes a 773-aa protein, the first 638 aa of which are common to both proteins. The PASD1-predicted protein contains a PAS domain that, together...
Source: Vaccine Weekly (2004-09-08)
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