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Malaria Vaccine
Splenic dendritic cell subsets prime and boost CD8 T cells
September 8th, 2004
Splenic dendritic cell subsets prime and boost CD8 T cells and are involved in the generation of effector CD8 T cells. According to published research from England, "The ability of the dendritic cell (DC) subsets, CD8alpha+ and CD8alpha- DCs, to initiate a CD8 T cell response or to activate memory CD8 T cells and generate effector CD8 T cells has been controversial. In this study, we analyze the capacity of splenic DC subsets to induce CD8 T cell responses to a CD8 T cell epitope (pb9) of a malaria antigen. The administration of peptide-pulsed CD8alpha- or CD8alpha+ DCs primes and boosts a primed CD8 T cell response against the malaria epitope." "In...
Source: Vaccine Weekly (2004-09-08)
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