Vaccine Weekly
Welcome to NewsRx!
Learn more about a six-week, no-risk free trial of Vaccine Weekly
We're a pay-per-view site for premium content. If you'd like to purchase this article, it's only $3.00.
Malaria Vaccine
Plasmodium antigen region elicits antibodies reactive with placental isolate
September 8th, 2004
A 67-amino-acid region of the Plasmodium falciparum variant surface antigen binds chondroitin sulfate A and elicits antibodies reactive with the surface of placental isolates. According to a study from the United States and France, "The complications of malaria in pregnancy are caused by the massive sequestration of parasitized erythrocytes (PE) in the placenta. Placental isolates of Plasmodium falciparum are unusual in that they do not bind the primary microvasculature receptor CD36 but instead bind chondroitin sulfate A (CSA). Pregnant mothers develop antibodies that recognize placental variants worldwide, suggesting that a vaccine against malaria in...
Source: Vaccine Weekly (2004-09-08)
|
