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Microencapsulation
Poly(lactic-co-glycolic acid)-based nanoparticulate system characterized
September 8th, 2004
Scientists have characterized poly(D,L-lactic-co-glycolic acid)-based nanoparticulate system for enhanced delivery of antigens to dendritic cells. "Biodegradable nanoparticles made of poly(D,L-lactic acid-co-glycolic acid) (PLGA) copolymer were characterized for enhanced delivery of antigens to murine bone marrow derived dendritic cells (DCs) in vitro. PLGA nanoparticles were efficiently phagocytosed by the DCs (CD11c+, MHC class II+, CD86+) in culture, resulting in their intracellular localization. The efficiency of the uptake was influenced by the incubation time and nanoparticle concentration," researchers in Canada report. "DCs pulsed with PLGA...
Source: Vaccine Weekly (2004-09-08)
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