Vaccine Weekly
Welcome to NewsRx!
Learn more about a six-week, no-risk free trial of Vaccine Weekly
We're a pay-per-view site for premium content. If you'd like to purchase this article, it's only $3.00.
Microencapsulation
Subcutaneous immunization allows uptake of diphtheria vaccine
September 8th, 2004
Subcutaneous immunization allows in vivo uptake of an experimental microencapsulated diphtheria vaccine. According to published research from England, "Previous studies demonstrated in vitro phagocytosis of poly(lactide-co-glycolide) (PLGA) microspheres (MS) by macrophages and dendritic cells and the biodistribution of fluorescent PLGA particles following oral or intranasal administration. In this study, we report the uptake and biodistribution of subcutaneously administered fluorescent-labeled PLGA MS loaded with diphtheria toxoid (DT). The cell type and percentage of fluorescent positive cells were determined by flow cytometry and confirmed by fluorescent...
Source: Vaccine Weekly (2004-09-08)
|
