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AIDS/HIV Vaccine
HIV-1 Tat(1-72) protein-coated nanoparticles elicit strong immune responses
September 8th, 2004
HIV-1 Tat(1-72) protein-coated nanoparticles generate strong T cell type-1 immune responses. "A significant emphasis has been placed on the development of adjuvants and/or delivery systems to improve both antibody production and cell-mediated immune responses. We previously reported on a novel anionic nanoparticle, which led to enhanced humoral and T helper type-1 (Th1) biased immune responses in mice when coated with cationized model antigen. Tat (1-72) is a conserved regulatory HIV-1 protein. It was hypothesized that HIV vaccine strategies employing Tat (1-72) may be a promising approach," scientists in the United States report. "Although previous...
Source: Vaccine Weekly (2004-09-08)
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