Smallpox Therapy

Antiviral prophylaxis of smallpox reviewed

Published in Vaccine Weekly, September 15th, 2004

Researchers review the antiviral prophylaxis of smallpox in a recent issue of the Journal of Antimicrobial Chemotherapy.

According to a study from the United States, "Proof-of-concept studies suggest that current defenses against smallpox could be strengthened by supplementing vaccination with antiviral drug prophylaxis, based on aerosolized or orally available forms of the long-acting medication cidofovir. Delivery of aerosolized cidofovir to mice results in its prolonged retention in respiratory tissues and protection against lethal intranasal or aerosol poxviral challenge. Although cidofovir itself is not orally available, the addition of an alkoxyalkanol...

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Source: Vaccine Weekly (2004-09-15)

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