Hepatitis C Vaccine
Hepatitis C virus mutation affects proteasomal epitope processing
Published in Vaccine Weekly, September 22nd, 2004
According to a study from the United States, "The high incidence of hepatitis C virus (HCV) persistence raises the question of how HCV interferes with host immune responses. Studying a single-source HCV outbreak, we identified an HCV mutation that impaired correct carboxyterminal cleavage of an immunodominant HLA-A2-restricted CD8 cell epitope that is frequently recognized by recovered patients. The mutation, a conservative HCV nonstructural protein 3 (NS3) tyrosine to phenylalanine substitution, was absent in 54 clones of the infectious source, but present in 15/21 (71%) HLA-A2-positive and in 11/24...
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Source: Vaccine Weekly (2004-09-22)
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