Pneumococcal Vaccine

Anti-polysaccharide IgG linked to pneumococcal disease risk in HIV-1

Published in Vaccine Weekly, October 6th, 2004

Anti-polysaccharide IgG antibodies are associated with the risk of invasive pneumococcal disease in Ugandan adults infected with HIV-1.

According to a study from Malawi, "We have investigated the association between the concentration of anti-polysaccharide pneumococcal capsule-specific (anti-PS) immunoglobulin G and the killing activity, in serum, in invasive pneumococcal disease (IPD) events and response to 23-valent polysaccharide vaccine in human immunodeficiency virus (HIV)-infected Ugandans. Case patients with IPD had lower concentrations of anti-PS IgG before and after vaccination and before the IPD event (p<0.01 for five [i.e., 4, 9V, 14, 18C, and 19F] of six...

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Source: Vaccine Weekly (2004-10-06)

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