Tuberculosis Vaccine

Microparticles adsorption enhances protection of TB vaccine

Published in Vaccine Weekly, October 6th, 2004

Adsorption onto cationic PLG microparticles enhanced the protective efficacy of a tuberculosis DNA vaccine.

"Immunization with plasmid DNA vectors represents a promising new approach to vaccination. It has been shown to elicit humoral and cellular immunity and protection in various infection models. Here, we assessed the immunogenicity and protective efficacy of a DNA vaccine vector encoding the antigen 85A (Ag85A) of Mycobacterium tuberculosis," researchers in Germany report.

"Since intramuscular (i.m.) immunization with naked DNA requires considerable amounts of DNA in order to be effective, we evaluated a strategy to reduce the amount of...

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Source: Vaccine Weekly (2004-10-06)

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