AIDS/HIV Vaccine

Immune responses to hemagglutinin/SHIV-like particle vaccine reported

Published in Vaccine Weekly, October 6th, 2004

Scientists report Th cell-independent immune responses to a chimeric hemagglutinin/simian human immunodeficiency virus-like particle vaccine.

"CD4+ Th cells are believed to be essential for the induction of humoral and cellular immune responses. In this study we tested the effect and possible mechanisms of the major antigenic component in influenza, hemagglutinin (HA), in helping HIV Env to induce immune responses in CD4+ T cell knockout (CD4 KO) mice. Simian HIV virus-like particles (SHIV VLPs) or phenotypically mixed chimeric influenza HA/SHIV VLPs were used as immunogens to immunize CD4 KO mice either i.p. or intranasally (i.n.)," investigators in the United States...

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Source: Vaccine Weekly (2004-10-06)

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