Immune Responses
Salmonella vaccine elicit immunity against foreign antigen in neonates
Published in Vaccine Weekly, October 13th, 2004
"The development of effective vaccines for neonates and very young infants has been impaired by their weak, short-lived, and Th-2 biased responses and by maternal antibodies that interfere with vaccine take. We investigated the ability of Salmonella enterica serovars Typhi and Typhimurium to mucosally deliver tetanus toxin fragment C (Frag C) as a model antigen in neonatal mice. We hypothesize that Salmonella, by stimulating innate immunity (contributing to adjuvant effects) and inducing Th-1...
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Source: Vaccine Weekly (2004-10-13)
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