Melanoma Vaccine
Antibodies elicit antigen-specific T cells in melanoma patients
Published in Vaccine Weekly, October 13th, 2004
"HLA-A2-restricted CTLs, which lysed high molecular weight (HMW)-melanoma-associated antigen (MAA)+ melanoma cells, were induced in patients with melanoma immunized with Melimmune, a combination of the murine anti-idiotypic (anti-id) monoclonal antibodies (mAb) MEL-2 and MF11-30. In the present study we investigated whether CTL epitopes are present in anti-id mAb MF-11-30 and activate T cells to recognize HMW-MAA on melanoma cells," scientists writing in the journal Cancer Research report.
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Source: Vaccine Weekly (2004-10-13)
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