Prostate Cancer

Monoclonal antibodies against prostate-specific antigen characterized

Published in Vaccine Weekly, October 13th, 2004

Researchers have characterized monoclonal antibodies against prostate-specific antigen produced by genetic immunization.

According to recent research from Finland, "Prostate-specific antigen (PSA) is the most important marker for prostate cancer. Antibodies against minor variants of PSA may be useful in the development of novel diagnostic tests for prostate cancer, but it has been difficult to produce such antibodies by protein immunization. In this study, we have compared the characteristics of monoclonal antibodies (MAbs) obtained by genetic immunization with those obtained by protein immunization. The whole coding region of PSA-cDNA was cloned in a mammalian...

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Source: Vaccine Weekly (2004-10-13)

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