Respiratory Syncytial Virus

V beta 14+ T cells mediate disease induced by RSV G glycoprotein

Published in Vaccine Weekly, October 20th, 2004

V beta 14+ T cells mediate the vaccine-enhanced disease induced by immunization with respiratory syncytial virus (RSV) G glycoprotein but not with formalin-inactivated RSV.

According to published research from the United States, "Mice immunized with respiratory syncytial virus G glycoprotein or with formalin-inactivated RSV (FI-RSV) exhibit severe disease following RSV challenge. This results in type 2 cytokine production and pulmonary eosinophilia, both hallmarks of vaccine-enhanced disease. RSV G-induced T-cell responses were shown to be restricted to CD4+ T cells expressing Vbeta14 in the T-cell receptor (TCR), and the deletion of these T cells resulted in less...

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Source: Vaccine Weekly (2004-10-20)

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