Published in Vaccine Weekly, October 27th, 2004
According to a study from the United States, "The oncogenic EBV protein LMP1 mimics a dysregulated CD40 receptor in vitro. To compare CD40 and LMP1-mediated events in vivo, transgenic mice were engineered to express mouse CD40 (mCD40tg) or a protein with extracellular mCD40 and cytoplasmic LMP1 (mCD40-LMP1tg). Transgenic and CD40-/- mice were bred so that only the transgenic CD40 molecule is expressed in B cells, macrophages, and dendritic cells."
"mCD40-LMP1tg mice had normal...
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