Epstein-Barr Virus

LMP1 expression induces hyperactivation of B lymphocytes

Published in Vaccine Weekly, October 27th, 2004

Expression of the cytoplasmic tail of the Epstein-Barr virus protein LMP1 in mice induces hyperactivation of B lymphocytes and disordered lymphoid architecture.

According to a study from the United States, "The oncogenic EBV protein LMP1 mimics a dysregulated CD40 receptor in vitro. To compare CD40 and LMP1-mediated events in vivo, transgenic mice were engineered to express mouse CD40 (mCD40tg) or a protein with extracellular mCD40 and cytoplasmic LMP1 (mCD40-LMP1tg). Transgenic and CD40^-/- mice were bred so that only the transgenic CD40 molecule is expressed in B cells, macrophages, and dendritic cells."

"mCD40-LMP1tg mice had normal...

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Source: Vaccine Weekly (2004-10-27)

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