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Respiratory Syncytial Virus

Infectious nontransmissible respiratory syncytial virus developed

Published in Vaccine Weekly, October 27th, 2004

Trans-complementation allows recovery of human respiratory syncytial viruses that are infectious but deficient in cell-to-cell transmission.

According to published research from the United States, "Human respiratory syncytial virus (HRSV) expresses three transmembrane glycoproteins: small hydrophobic protein SH, attachment protein G, and fusion protein F. The genes encoding SH and G can be deleted from the HRSV genome and infectious virus recovered. In contrast, HRSVs lacking the F gene or a functional replacement thereof have not been reported. To generate a system with which to study the roles of the viral transmembrane glycoproteins, including F, in the HRSV life...

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