Immunology
Peptide-HSP70 complexes generate cytolytic T-lymphocyte responses
Published in Vaccine Weekly, November 3rd, 2004
According to recent research published in the journal Biochemical Society Transactions, "Microbial HSPs (heat-shock proteins) are implicated in the induction of the innate and adaptive arms of the immune response. We set out to determine whether peptides complexed with HSP70 generate efficient CTL (cytolytic T-lymphocyte) responses. Human dendritic cells pulsed with peptide-loaded microbial HSP70 complexes generate potent antigen-specific CTL responses."
"Using fluorescence anisotropy, we have calculated the peptide-binding affinity of...
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Source: Vaccine Weekly (2004-11-03)
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