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Vaccine Weekly

Susan Hasty, Publisher

Table of Contents . . . November 10th, 2004

Non-Subscriber - Summaries Only

Related Areas: Other Issues in Vaccine Weekly | Other Publications

Anthrax Vaccine - Capsule of Bacillus anthracis behaves as type 2 antigen

Chlamydia Vaccine - Novel recombinant multisubunit vaccine against Chlamydia developed

Malaria Vaccine - Acidic-basic repeat antigen protein peptide protects against malaria

Malaria Vaccine - Dendritic cells induce immunity against blood-stage malaria

Mucosal Immunization - NALT- versus Peyer's-patch-mediated mucosal immunity reviewed

AIDS/HIV Vaccine - HDAC inhibitors reactivate HIV-1 expression in cellular reservoirs

AIDS/HIV Vaccine - Macaques infected with attenuated SIV remain resistant to challenge

Allergy Medicine - Antibodies recognizing Bet v 1 and Humicola lanuginosa lipase isolated

Alzheimer Disease - Response to human and rodent A-beta peptide is species-specific

Anti-Infectives - Antibody fusion protein coupled to glucose oxidase is bactericidal

Asthma Vaccine - Arthropod-derived histamine-binding protein prevents allergic asthma

Bioterrorism - Report finds pharma, government and academia agree on bioterrorism danger

Bordetella - Culture and PCR for Bordetella detection compared

Breast Cancer Vaccine - Vaccine for prevention of HER2 mammary carcinomas under development

Business & Finance - Gene-identification company provides 2004 update

Business Update - New research facility opened in Boston

Cancer Vaccine - CD4+CD25+ T cells are preferentially induced by vaccine vector

Cancer Vaccine - Cancer immunotherapy beyond current vaccines reviewed

Cancer Vaccine - GM-CSF vaccines impair immune response via myeloid suppressor cells

Cancer Vaccines - Nano-vaccines exhibit therapeutic and protective effects against tumors

Coxsackievirus - Coxsackievirus replication and duration in intestinal cells described

Cryptococcus - Resistance to Cryptococcus dependent on maturation of NKT cells

Dendritic Cell Vaccine - Alpha-type-1 polarized dendritic cells optimize CTL-inducing activity

Dendritic Cells - SIRP- subset enriched in lymph dendritic cells from digestive tract

Dengue Vaccine - Encephalitis/dengue 4 virus chimera exhibits lack of neuro-invasiveness

Dengue Vaccine - The changing epidemiology of yellow fever and dengue reviewed

Drug Development - Vaccine developer receives U.S. HHS contract and grant to study innate immunity

Encephalomyelitis - CD5 plays critical role in experimental autoimmune encephalomyelitis

Epstein-Barr Virus - Immune responses against Epstein-Barr virus are varied

Finance - Biotech listed as one of Maryland's fastest-growing technology companies

Finance - Cancer vaccine maker reports loss of $0.54 per share

Finance - Dutch biotech reports increased Q3 revenues

Gastric Cancer Vaccine - OK-432 after surgery for gastric cancer did not improve survival rate

Generic Drugs - Generics association: Flu vaccine shortage highlights need for biogenerics

HIV/AIDS Awareness - AIDS Project Los Angeles honors AIDS Walk founder, marks 20 years of AIDS Walks

Helicobacter -  Helicobacter pylori infection of primary gastric cells investigated

Helicobacter - IgA better than IgG in Helicobacter-related urease activity inhibition

Helicobacter - Noninvasive method for monitoring H. pylori infection developed

Helicobacter Vaccine - Immunity against H. pylori impaired in IL-18-deficient mice

Herpesvirus - DNA vaccine trial initiated for treatment of herpes simplex type 2

Herpesvirus - Mutations in herpes glycoprotein prevent cell entry via nectins

Immunology - CD4+ T cells needed to maintain memory CD8+ T cells after infection

Immunology - Co-infection affects outcome of Helicobacter and Toxoplasma infections

Infectious Disease - Mini-clinic to offer flu diagnostic in Minneapolis and Baltimore

Infectious Disease - Studies show promise for respiratory disease vaccine

Influenza - Empire Blue Cross Blue Shield to cover FluMist

Influenza - Health experts warn Californians about importance of immunizations

Influenza - Insurance group covers FluMist vaccine for influenza as injection alternative

Influenza Vaccine - Health department asks vaccines only be administered to high-risk individuals

Influenza Vaccine - IgA antibodies protect different strains of influenza B virus

Influenza Vaccine - Pharma company developing new flu vaccine

Influenza Virus - Antigenic change in influenza virus linked to glycosylation site loss

Influenze Vaccinations - Box of flu shots destroyed after mistake at West Allis hospital in Wisconsin

Influenze Vaccine - Mothers, infants line up for flu shots

Influenze Vaccine - U.S. Health Secretary Tommy Thompson tells elderly not to wait in line

Legal Issues - Texas to sue flu shot distributors

Leishmaniasis - Current situation and new perspectives on leishmaniasis outlined

Leukemia - Histone deacetylase inhibition improves leukemic blast differentiation

Malaria - Multilateral malaria research and control programs are most successful

Malaria - Proteases in host cell invasion by malaria parasites reviewed

Malaria Vaccine - New and needed research relating to malaria reviewed

Malaria Vaccine - P domain of P0 protein of P. falciparum protects against malaria

Malaria Vaccine - Parameters of attenuated schistosome vaccine evaluated in olive baboon

Malaria Vaccine - Policy challenges in malaria vaccine introduction outlined

Melanoma - Data presented on peptide vaccine for melanoma

Melanoma Vaccine - Determinant spreading indicates antitumor response in melanoma therapy

Melanoma Vaccine - Effector-memory T-cell responses characterized in melanoma peptide vaccine

Melanoma Vaccine - New developments in melanoma research reviewed

Melanoma Vaccine - Toxicity of systemic IL-2 in conjunction with melanoma vaccine assessed

Mucosal Immunization - Intranasal vaccine adjuvant does not cause inflammation

Mucosal Immunization - TGF-beta receptor signaling is critical for mucosal IgA responses

Muscle Wasting - Mechanism discovered for muscle wasting seen in diabetes, AIDS, other diseases

Mycobacteria -  M. tuberculosis virulence locus regulates DNA transfer in M. smegmatis

Personnel - Jill M. Church appointed as chief financial officer by biopharm research company

Pertussis - Subassemblies of pertussis toxin subunits analyzed in vivo

Pertussis - Whooping cough makes a national comeback

Pneumococcal Vaccine - Immune response reduced to pneumococcal vaccine plus pertussis vaccine

Pneumococcal Vaccine - Phosphodiester bond hydrolysis in pneumococcal polysaccharides studied

Pneumococcal Vaccine Streptococcus - Prevalence of Streptococcus pneumoniae in Belgian infants reported

Pneumonic Plague - U.S. NIH allergy institute awards $50 million for recombinant protein vaccine

Prion Disease - Monoclonal antibody panel against mammalian prion protein established

Protein Synthesis - Recombinant baculovirus generates hepatitis B protein in silkworm larvae

Proteomics - ATM protein purified from vaccinia virus expression system

Pseudomonas -  Pseudomonas K122-4 pilin has receptor-binding architecture

PuntaToro Virus - Efficacy of JuvImmune platform evaluated in PuntaToro virus infection models

Reproductive Medicine - Animal models of inhibin action reviewed

Rheumatoid Arthritis - Pneumococcal vaccinations prove acceptable for RA patients

Rubella Vaccine - Rubella vaccination does not cause congenital rubella syndrome

Scabies Vaccine - Th1/Th2 immune response to Sarcoptes scabiei skewed

Schistosomiasis - Antigen-presenting cells exposed to cercariae activate lymphoid cells

Schistosomiasis - Schistosome cholesterol depletion promotes antibody binding to antigen

Scorpion Venom - Protective antibodies raised by scorpion venom toxins conjugated to BSA

Smallpox - Second U.S. government MVA smallpox vaccine contract awarded

Sporothrix - Chronic granulomatous disease impairs defense against Sporothrix

Tuberculosis - Interferon-gamma RNA expression low in tuberculosis patients

Tuberculosis Prevention - New vaccine boosts antituberculosis immunity

Tuberculosis Vaccine -  M. tuberculosis dehydrogenases show strong B cell response

Tuberculosis Vaccine -  M. tuberculosis genotypes cause wide range of immune responses

Tuberculosis Vaccine -  M. tuberculosis-induced IL-6 and IL-10 dependent on TLR2 recognition

Tuberculosis Vaccine - Immunity to M. tuberculosis hemagglutinin is methylation-dependent

Tuberculosis Vaccine - Influence of BCG organisms in vaccinated mice on TB immunity determined

Tularemia - Lipid A of Francisella tularensis modified

Tularemia Vaccine - Sublethal Francisella infection causes only marginal immunity

Vaccinations - Canada may have more than 2 million surplus doses of vaccine

Vaccine Adjuvant - Liposomes prepared from BCG possessed adjuvant activity in vivo

Vaccine Development - European patent awarded for nicotine addiction vaccine

Vaccine Development - FDA grants fast-track designation for staph vaccine

Vaccine Development - Human vaccine developer provides update on business activities

Vaccine Development - New agreement includes tuberculosis subunit vaccine development

Vaccine Development - Subclinical infections in injection drug users provide hepatitis C prophylaxis

Vaccine Efficacy - Optimal vaccination schemes to prevent epidemics estimated

Vaccine Efficacy - Vaccine efficacy estimated using a small validation sample

Vectors and Zoonoses - Current status of medical entomology in France reviewed

Virology Vaccine - Removal of T cell help improves virus-neutralizing antibody production

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