Tularemia Vaccine

Sublethal Francisella infection causes only marginal immunity

Published in Vaccine Weekly, November 10th, 2004

Mice sublethally infected with Francisella novicida U112 develop only marginal protective immunity against systemic or aerosol challenge with virulent type A or B strains of F. tularensis.

According to recent research from Canada, "The current study determined the ability of Francisella novicida to act as a live vaccine against the much more virulent, but closely related pathogen, Francisella tularensis. Live attenuated strains of the latter are effective vaccines against human tularemia. However, the molecular cause of their attenuation remains unknown, and this is a regulatory barrier for licensing such vaccines."

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Source: Vaccine Weekly (2004-11-10)

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