Anthrax Vaccine

Capsule of Bacillus anthracis behaves as type 2 antigen

Published in Vaccine Weekly, November 10th, 2004

The capsule of Bacillus anthracis behaves as a thymus-independent type 2 antigen.

"Bacillus anthracis elaborates a homopolymeric capsule composed Of T-D-glutamic acid residues. Mice were immunized with formalin-fixed encapsulated B. anthracis bacilli, and the serum antibody response to a gamma-D-glutamyl capsular epitope was measured," scientists in the United States report.

"Antiglutamyl antibodies were elicited in athymic BALB/c Nu/Nu, BALB/c Nu/+, and CBA/J mice but not in CBA/N xid mice," stated Taia T. Wang and Alexander H. Lucas at Children's Hospital Oakland Research Institute. "These response patterns define the capsule...

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Source: Vaccine Weekly (2004-11-10)

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