Malaria Vaccine

Parameters of attenuated schistosome vaccine evaluated in olive baboon

Published in Vaccine Weekly, November 10th, 2004

Scientists have evaluated the parameters of the attenuated schistosome vaccine in the olive baboon.

According to a study from England and Kenya, "Five exposures of baboons to the attenuated schistosome vaccine gave greater protection than three exposures, but this attenuation was not sustained when challenge was delayed. Within the scope of the data collected, fecal egg counts and circulating antigen levels did not accurately predict the observed worm burdens."

"Levels of immunoglobulin G at challenge correlated best with protection, but there was little evidence of a recall response," reported Thomas M. Kariuki at the Institute of Primate Research...

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Source: Vaccine Weekly (2004-11-10)

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