AIDS/HIV Vaccine

HDAC inhibitors reactivate HIV-1 expression in cellular reservoirs

Published in Vaccine Weekly, November 10th, 2004

Administration of HDAC inhibitors reactivate HIV-1 expression in latent cellular reservoirs.

"The discovery of powerful antiviral compounds in the 90's raised the hope that the human immunodeficiency virus type I (HIV-1) might be eradicated. However, if these drugs succeed in decreasing and controlling viral replication, complete eradication of the virus is nowadays impossible. The persistence of virus even after long periods of highly active antiretroviral therapy (HAART) mainly results from the presence of cellular reservoirs that contain transcriptionally competent latent viruses capable of producing infectious particles after cellular activation," investigators in...

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Source: Vaccine Weekly (2004-11-10)

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