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Malaria Transmission

Antibodies immobilize Plasmodium sporozoites injected by mosquitoes

Published in Vaccine Weekly, November 17th, 2004

Intravital microscopy indicates antibody-mediated immobilization of Plasmodium berghei sporozoites injected into skin by mosquitoes.

According to recent research from the United States, "Previous studies have shown that mosquitoes inject Plasmodium sporozoites into avascular portions of the skin of their rodent host rather than directly into the blood circulation. Then, over time, these sporozoites move into the circulation, from where they reach the liver to initiate a malaria infection."

"By use of intravital microscopy of the skin, we present direct morphological evidence of mosquito probing that introduces sporozoites into avascular...

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