Published in Vaccine Weekly, November 24th, 2004
"We have investigated the ability of HIV-1 protease to cleave human complement proteins of the classical complement pathway: C1q, C2, and C4 as well as the regulatory protein, C1-inhibitor. Purified complement proteins were incubated with recombinant HIV-1 protease in vitro and analyzed by SDS-PAGE and immunoblotting assay. The only cleavage site was found in N-terminal region of C1-inhibitor, and it was located between residues Leu-32 and Phe-33 as determined by amino acid sequence analysis of the 85-kDa proteolytic fragment after 12 Edman degradation cycles," scientists in Croatia...
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