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Vaccine Weekly

Susan Hasty, Publisher

Table of Contents . . . December 1st, 2004

Non-Subscriber - Summaries Only

Related Areas: Other Issues in Vaccine Weekly | Other Publications

Dengue Vaccine - Mutations in dengue virus vaccine candidate decreases virus replication

Prion Disease - Recent developments in prion immunotherapy reviewed

SARS Vaccine - Immunodominant sites on spike protein of SARS coronavirus identified

Smallpox Vaccine - Myopericarditis reported following smallpox vaccination

Vaccine Development - Prime-boost strategy developed using Salmonella enterica Typhi

AIDS/HIV Vaccine - AIDS protection dependent on persistence of vaccine virus

AIDS/HIV Vaccine - HIV-1 Tat protein modulates generation of cytotoxic T cell epitopes

AIDS/HIV Vaccine - HIV-1 Tat vaccine protects against SHIV89.6P replication in monkeys

AIDS/HIV Vaccine - Inflammatory stimuli increase neutrophil binding of HIV

AIDS/HIV Vaccine - Pseudoviruses encoding gag induces HIV gag-specific mucosal immunity

AIDS/HIV Vaccine - Retroviral vectors used to analyze SIV/HIV-specific T cell responses

AIDS/HIV Vaccine - nef-deleted SHIV protects against pathogenic virus infection

Alzheimer Disease - Beta-sheet breaker peptide prevents Alzheimer's memory impairments

Alzheimer Disease - Complications of Alzheimer vaccination in nonhuman primates modeled

Alzheimer Disease - Neuroscientists awarded $1.1 million grant to improve Alzheimer vaccine

Anthrax - Company gets $877.5 million U.S. government contract to supply anthrax vaccine

Anthrax Vaccine - Plasmid DNA vaccine protects against aerosolized anthrax spores

Anthrax Vaccine - Vaccine protects cheetah and black rhinoceros against anthrax

Autoimmune Disease - Virus-induced auto-antibody responses characterized

Breast Cancer - Investigators awarded grants from U.S. DoD Breast Cancer Research Program

Business & Finance - Immunotherapeutics company sees Q3 revenue increase

Business & Finance - Pharma company reports third quarter 2004 results

Cancer Vaccine - Antibodies redirect cytolytic capacity of cytotoxic T lymphocytes

Cancer Vaccine - Cancer vaccines must break immune tolerance to malignant cells

Cancer Vaccine - IL-6 regulates dendritic cell differentiation through STAT3 activation

Cancer Vaccine - Lipid-core-peptides increase adjuvant activity of T cell peptides

Cancer Vaccine - Melanoma vaccination results presented at conference

Cancer Vaccine - PHB1/PHB2 identified as blood-borne tumor antigens

Cancer Vaccine - Susceptibility of tumors to immunotherapy changes during maturation

Canine Distemper Virus - DNA vaccine protects against lethal canine distemper virus challenge

Cervical Cancer - HPV vaccine shown to "substantially" reduce cervical cancer

Clinical Update - Company details clinical development plan for CG53135 and CR002

Contraception - Studies in male monkeys demonstrate that immunocontraception could work

Diabetes - Research institute announces discovery on the virus' role in autoimmune disease

Diabetic Nephropathy - Data show FG-3019 improves kidney function in late-stage disease model

Diagnostics - Whole blood cytokine detection assay to quantitate T-cells developed

Diarrhea - Treatment of diarrhea and dysentery in Thailand described

Diphtheria-Tetanus Vaccine - Persistent itching nodules caused by diphtheria-tetanus toxoid vaccines

Dysentery Vaccine - Cultural context of dysentery has implications for vaccine introduction

Encephalitis Vaccine - Formaldehyde-inactivated Japanese encephalitis virus vaccine developed

Encephalomyelitis - Autoimmune encephalomyelitis cured by Trypanosoma cruzi infection

Epstein-Barr Virus - Epstein-Barr virus antigen elicits anti-dsDNA and anti-Sm antibodies

Escherichia Coli - Repeated boosting with E. coli bacterin needed for high antibody levels

Finance - Biophharmaceutical company reports cash position, net cash expenditures for Q3

Finance - Drug developer of upper respiratory therapies reports third quarter financials

Finance - Genetics-based company reports third quarter 2004 financial results

Finance - TNFerade maker reports increase in revenues, dip in losses during Q3

Genomics - Biotechnology company submits re-examiniation request for Benitec

HIV/AIDS - Infectech, Inc., reports validation of mycobacteria avium complex kit

HIV/AIDS - New information on TRIZIVIR presented at conference

HIV/AIDS - Pharma company files application with FDA for antiretroviral agent

HIV/AIDS - Phase II data for HIV drug presented at conference

HIV/AIDS - Phase IIa study show Reverset potentially reduces HIV viral load

HIV/AIDS - VScan HIV test kits are being shipped to Japan

HIV/AIDS Therapy - Indian firm withdraws its HIV drugs from World Health Organization list

Hepatitis - Trial results for spi-VECTM oral immunotherapeutic vaccine reported

Hepatitis B - Britain should adopt universal hepatitis B immunization, says doctor

Hepatitis B - European authorities give positive opinion for Fendrix vaccine

Hepatitis B - Outbreak of hepatitis B in drug users causes high mortality

Hepatitis B Virus - Phase II trial data announced on new HBV vaccine

Herpesvirus - Aggresome-like structures form in herpes virus type 2-infected cells

Herpesvirus - Tests for antibodies against bovine herpesvirus 1 evaluated

Herpesvirus Vaccine - In vivo function of gamma-herpesvirus virion glycoprotein described

Human Immunodeficiency Virus - Structure of anti-human immunodeficiency virus type 1 antibody 2F5 reported

Immunization - Comprehensive screening detects new epitopes in hepatitis C virus NS3 antigen

Immunizations - Financial challenges of immunization reviewed

Immunology - Marginal zone B cells deposit immune complexes onto dendritic cells

Immunology - Oral mucosal immunology reviewed

Infectious Disease - Research institute announces $12 million in NIH contracts for smallpox research

Infectious Disease - Study compares hepatitis B treatments

Influenza - 340,000 doses of influenza vaccine to be distributed in Pennsylvania

Influenza - CDC and states announce plan to distribute 10.3 million flu shots nationwide

Influenza - CDC to include FluMist in vaccines for children program

Influenza - Computerized orders increase administration of influenza, pneumococcal vaccines

Influenza - Flu preparedness must become public health priority

Influenza Vaccine - 15,000 people request a flu shot in Arizona county vaccine lottery

Influenza Vaccine - Additional doses of flu vaccine available for at-risk people in Louisiana

Influenza Vaccine - Alaskan health officials begin distributing more flu vaccine

Influenza Vaccine - Aventis gets federal contract to make flu vaccine year-round

Influenza Vaccine - Colorado getting another 66,000 flu shots

Influenza Vaccine - Connecticut receives unexpected batch of flu vaccine

Influenza Vaccine - Enrollment complete for intranasal influenza vaccine trial

Influenza Vaccine - Flathead County, Montana, plans one more clinic with surprise flu shots

Influenza Vaccine - Inactivated vaccines for pandemic influenza reviewed

Influenza Vaccine - Kansas to receive 75,360 doses of flu vaccine from CDC

Influenza Vaccine - More flu vaccine headed to Iowa

Influenza Vaccine - Nanoparticle and emulsified influenza antigen vaccines developed

Influenza Vaccine - New Hampshire's order of flu vaccine arrives

Influenza Vaccine - North Dakota getting more flu vaccine

Influenza Vaccine - One million high-risk Pennsylvanians still can't get flu shots

Influenza Vaccine - Pennsylvania to get 340,000 additional doses of flu vaccine

Influenza Vaccine - Study of avian influenza in birds and humans may help develop vaccines

Influenza Vaccine - U.S. CDC to ship New Mexico 38,515 additional flu vaccine doses

Influenza Vaccine - Vermont Health Department, health agencies offered more flu clinics

Influenza Vaccine - Virginia health officials to get 232,000 doses of flu vaccine

Influenza Vaccine - Yuma County, Arizona, distributes flu vaccine to elderly

Malaria Vaccine - Quantitative Plasmodium sporozoite neutralization assay developed

Marek Disease - Mutations in meq linked to Marek disease viruses of high virulence

Measles-Rubella Vaccine - Rapid onset optic neuritis after measles-rubella vaccination reported

Melanoma Vaccine - Vaccine induces cytotoxic T lymphocytes in human melanoma

Monoclonal Antibodies - Method for production of antibody-producing hybridomas developed

Mucosal Immunization - Adjuvants and delivery systems for mucosal vaccination reviewed

Mucosal Immunization - Mucosal immunology of vaccines against nasopharyngeal bacteria reviewed

Mycoplasma Vaccine -  Mycoplasma agalactiae strain is candidate for attenuated vaccine

Newborn Health - Respiratory syncytial virus trial initiated

Parvovirus Vaccine - Immune responses to human parvovirus B19 vaccine reported

Personnel - Life sciences company names member to board of directors

Personnel - Molecular test producer announces president for its U.S. subsidiary

Poliovirus - Heat-resistant poliovirus mutants characterized

Poliovirus Vaccine - Surrogate method for predicting poliovirus vaccine efficacy developed

Poxvirus Vaccine - Nucleoside/nucleotide analogs show promise against poxvirus infections

Prostate Cancer - E.U. approves Taxotere (docetaxel) in prostate cancer

Prostate Cancer - Pharma companies awarded NIH grants for prostate cancer immunotherapies

Rabies Vaccine - Live vaccinia-rabies virus recombinants protect against rabies

Reovirus Vaccine - Protective IgA and IgG bind to epitopes in reovirus adhesin sigma 1

Research Awards - Molecular studies institute wins $4.8 million NIH contract for smallpox vaccine

Ricin Vaccine - Elimination of partially unfolded state improves vaccine stability

Rotavirus Vaccine - T-cell-mediated immune responses in rotavirus infections defined

Rubella - German measles elimination advancing, says public health group

SARS Vaccine - Researcher says SARS vaccine unlikely soon; drug companies show scant interest

Schistosomiasis Vaccine -  Schistosoma antigen protects against S. mansoni infection

Schistosomiasis Vaccine - Antigen peptides from Schistosoma dehydrogenase used for vaccines

Shigellosis - IL-8 regulates neutrophil recruitment in model of Shigella colitis

Shigellosis Vaccine - Acceptability of shigellosis vaccine in Vietnam explored

Shigellosis Vaccine - Health belief model aids shigellosis vaccine use in Thailand

Smallpox Vaccine - Membrane proteins of virions protects against vaccinia virus

Tuberculosis - Licensing agreement signed to develop, market new antituberculosis compounds

Tuberculosis Prevention - New TB vaccine clears first hurdle

Tuberculosis Vaccine - Mammalian cell-entry proteins expressed during TB infection in humans

Tumor Vaccine - Therapeutic HER2/Neu DNA vaccine blocks the growth of murine tumors

Typhoid Vaccine - Vaccination against typhoid fever in travelers is not cost-effective

Vaccine Adjuvant - Adjuvant Quil A affects immune stimulatory capacity of liposomes

Vaccine Development - Applications of Clostridium and Bacillus proteins reviewed

Vaccine Development - CD8+ T-cell priming regulated by cytokines of innate immune system

Vaccine Development - Coadministered antigens may afford better protection against hepatitis B

Vaccine Development - Company says skin immunization may expand flu vaccine supply

Vaccine Development - DNA vaccine aids chronic hepatitis B carrier non-responders

Vaccine Development - Pharma company releases results from Boostrix clinical study

Vaccine Development - Vector-based enhancement of ICAM-1 augments anti-tumor activity in mice

Vaccine Efficacy - Game theory applied to vaccination strategies

Vaccine Safety - H2 O2 -induced death of thymocytes delayed by vaccine preservative

Varicella Vaccinations - Arizona health officials pushing plan for chickenpox vaccinations

Virology - Long-term immune memory cells do not develop during chronic viral infections

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