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Vaccine Weekly

Susan Hasty, Publisher

Table of Contents . . . December 8th, 2004

Non-Subscriber - Summaries Only

Related Areas: Other Issues in Vaccine Weekly | Other Publications

Immunization - Continuous antigenic stimulation is new immunization strategy

Malaria Vaccine - Immunogenicities of Plasmodium vivax protein fragments compared

Malaria Vaccine - Merozoite protein protects against lethal malaria parasite challenge

SARS Virus - Native form of recombinant SARS coronavirus spike glycoprotein characterized

Tuberculosis Vaccine - BCG can subvert monocyte differentiation into dendritic cells

AIDS/HIV Pathogenesis - CD4+ T cell depletion in HIV occurs predominantly in gastrointestinal tract

AIDS/HIV Vaccine - Novel and promiscuous CTL epitopes in conserved regions of Gag identified

AIDS/HIV Vaccine - Therapeutic HIV vaccines reviewed

AIDS/HIV Vaccine - Vaccine provides T-cell-mediated protection in monkeys after SIV challenge

Actinomycetoma Vaccine - IgM protects mice from actinomycetoma infection by Nocardia brasiliensis

Addiction Medicine - Cocaine pharmacology and pharmacotherapies for its abuse reviewed

Adverse Side Effects - Rare cutaneous reactions arise following hepatitis B vaccine immunization

Allergy Medicine - Parenteral immunization to beta-lactoglobulin modifies intestinal structure

Alzheimer Disease - Immune responses to A-beta vaccine are different in C57BL/6 and B6D2F1 mice

Alzheimer Disease - Inhibitors of A-beta oligomerization identified

Anthrax - Company completes first phase of ThraxVax design

Aspergillosis - CpG oligodeoxynucleotides modulate airway inflammation in aspergillosis model

Awards - Fluid diagnostics company receives award

Biological Therapy - Type-1 innate and acquired immunity play crucial roles in tumor immunotherapy

Breast Cancer - Phage display library from lymph nodes of breast cancer patients constructed

Business & Finance - Biopharma reports third quarter 2004 results, clinical achievements

Business Update - Molecular diagnostics company announces expansion of diagnostic pipeline

Business Update - New company to develop, produce patient-specific cancer vaccines

Cancer Immunoprevention - Fused cell vaccination and CpG oligodeoxynucleotides reject tumor recurrence

Cancer Therapy - Skin cancer study using MedPulser Electroporation Therapy system begins

Cancer Vaccine -  Listeria-based cancer vaccines segregate immunogenicity from toxicity

Cancer Vaccine - Dendritic cells boost antitumor activity of adoptively transferred T cells

Cancer Vaccine - Expression of the cell surface mucin gene family in adenocarcinomas reported

Cancer Vaccine - IL-13 antagonist and Pseudomonas toxin fusion protein is anticancer

Cancer Vaccine - Tumor vaccine therapy reviewed

Cancer Vaccines - Interleukin-15 transfection plus CD8+ T cells cause colon cancer rejection

Cholera Vaccine -  Vibrio cholerae amino acid sequence induces protective antibodies

Cognition - Immunization may have long-term effects on cognitive performance

Collaborations - Anti-cancer vaccine R&D agreement signed

Cryptococcus Vaccine - Immunoglobulin against Cryptococcus glucuronoxylomannan is protective

DNA Vaccine - DNA vaccines induce epitope-specific CTLs against histocompatibility antigens

Dengue Virus - Dengue viral infections reviewed

Diphtheria Vaccine - Respiratory epithelial cells internalize Corynebacterium diphtheriae

Disease Prevention - African leaders, health activists push for money to fight disease

Drug Development - Cervical cancer's image as a niche market hinders drug development

Encephalomyelitis - ICAM-1 upregulation in allergic encephalomyelitis depends on TNF-alpha

Finance - INTERCEPT maker reports Q3 revenue of $3.5 million

Finance - Immune-focused company announces Q3 net loss of $4M

Finance - Transdermal drug delivery technology company reports Q3 financial results

Finance - Vaccine company adopts shareholder rights plan

HIV Treatment - Monoclonal antibody among HIV therapies discussed at human virology meeting

HIV/AIDS Prevention - Russian government lacks will to combat spread of HIV/AIDS, experts say

HIV/AIDS Treatment - Canadian HIV partnership lends financial support to phase 2 clinical drug trials

HIV/AIDS Treatment - Data involving Combivir presented at recent meeting

HIV/AIDS Vaccine - Role of gastrointestinal T cells in HIV pathogenesis reviewed

Helicobacter Vaccine - Mechanisms of vaccine-induced protection against H. pylori reviewed

Hemorrhagic Fever - Signal peptide of arenavirus glycoprotein forms mature G1-G2 complex subunit

Hepatitis C Virus - Payment received from GlaxoSmithKline relating to HEV vaccine

Human Papillomavirus - Inflammatory responses in cervical neoplasia suppressed in HIV-positive women

Human Papillomavirus - Methods of identifying new antigenic epitopes of HPV 16 developed

Human Papillomavirus - Prevalence of HPV infection differs for men and women

Human Papillomavirus Vaccine - Dendritic cell-based vaccines effective against HPV-associated tumors

Immunization - Accelerated hepatitis B vaccine schedules protect prisoners better

Immunology - B subunit of E. coli enterotoxin induces apoptosis in CD8+ T cells

Immunology - B1b lymphocytes confer T cell-independent long-lasting immunity

Immunology - Chemokine receptor-mediated delivery induces protective immunity in vivo

Immunology - Heat shock protein suicide gene-based tumor vaccine provokes antitumor activity

Immunology - Intestinal epithelial antigen induces mucosal CD8 T cell tolerance

Immunology - LFA-1 on CD4+ T cells required for optimal antigen-dependent activation

Immunology - Nondepleting CD4 antibody induces immunological tolerance in baboons

Immunology - Role of IgG2b in mucosal tolerance induction investigated

Influenza - WHO says flu vaccine coming within year

Influenza Outbreak - Flu season starts in Oregon

Influenza Vaccine - Alabama nursing homes still waiting for flu shots

Influenza Vaccine - Chiron asks British regulators to inspect flu vaccine facility

Influenza Vaccine - HHS head Thompson announces contract to support egg supply for flu vaccines

Influenza Vaccine - Hawaii opens flu shot clinics for chronically ill

Influenza Vaccine - Ineffective vaccine given to about 300 in Arkansas, health official says

Influenza Vaccine - Senator says money for new flu vaccine research probably on the

Influenza Vaccine - Utah lifting flu shot restrictions

Influenza Vaccine - Vermont to hold 17 flu shot clinics

Leishmaniasis Vaccine -  Leishmania major exogenous antigens protects against infection

Leishmaniasis Vaccine - Central memory T cells mediate long-term immunity to Leishmania major

Leishmaniasis Vaccine - T cells mediate immunity to Leishmania major in absence of parasites

Leukemia Vaccine - Leukemic cells have high B7-H1 and B7.1 expression and resist lysis

Listeria Vaccine -  Listeria monocytogenes aro mutants show promise as vaccine candidates

Lung Cancer - Cancer vaccine helped patients in phase IIb trial survive 4.4 months longer

Lyme Disease -  Borrelia burgdorferi changes antigens based on host immune response

MMR Vaccine - Differential immune responses to MMR vaccine in Israeli children documented

Malaria Vaccine -  Plasmodium yoelii proteins enhance protection against malaria

Malaria Vaccine - Anatomy of Plasmodium falciparum MSP-1 epitope mapped

Malaria Vaccine - Antigenic drift in Plasmodium vivax protein confers antibody resistance

Measles Vaccine - Measles vaccination rate in developed world

Melanoma - Data updates from phase 2 trial for metastatic melanoma drug presented

Melanoma Vaccine - Quiescent phenotype of tumor-specific CD8+ T cells following immunization

Meningitis Vaccine - Protection against N. meningitidis found without bactericidal activity

Meningococcal Vaccine - Distribution of protein variants among meningococci aids vaccine design

Meningococcal Vaccine - Intranasal immunization with liposomes plus meningococcal proteins studied

Mergers & Acquisitions - Biotechnology company amends merger agreement with HIV-focused pharm firm

Mergers & Acquisitions - Biotechnology holding company signs agreement to acquire Portage Biomed

Mergers & Acquisitions - Company amends merger agreement with V.I. Technologies

Neuropathy - Immunization protocols for motor axonal neuropathy rabbit model compared

Oncogenesis - Aged mice develop protective antitumor immune responses with costimulation

Oncology - Combined chemotherapy and immunotherapy generates tumor rejection

Patents - Canada-based biotechnology company receives U.S. patent for vaccine production

Pediatrics - Pediatric nutrition company lists steps to keep families well during flu season

Personnel - Biopharmaceutical company names new chief executive officer

Personnel - Flu vaccine maker names Jack Goldstein interim COO, Anne Hill VP of HR

Personnel - Haig takes over from father as chairman of the board

Pneumococcal Vaccine -  Streptococcus pneumoniae protects against fatal pneumococcal challenge

Pneumococcal Vaccine - Multiplex opsonophagocytosis assay useful to monitor pneumococcal vaccine

Pneumonia - Seniors in South Carolina urged to get pneumonia shots

Preventive Medicine - Despite setbacks, strong growth seen in $7 billion vaccine market

Renal Cancer - Dendritic cell-tumor fusion vaccines being developed for renal cell carcinoma

Renal-Cell Cancer - Allogeneic stem-cell transplantation for renal-cell cancer reviewed

Respiratory Syncytial Virus - Signaling via prostaglandin receptor protects against RSV

Salmonella Vaccine - Attenuated Salmonella mutants cause fatal infections in mice

Salmonella Vaccine - B7 costimulatory molecules play role in antibody responses to Salmonella

Salmonella Vaccine - Delta yej Salmonella mutants induce superior CD8+ T-cell responses

Salmonella Vaccine - Live Salmonella vaccine protects against Salmonella enteritidis

Schistosomiasis Vaccine - Vaccine protects against tetanus and schistosomiasis in mice

Staphylococcus - Sigma factor B required for virulence in Staphylococcus aureus

Streptococcus Vaccine - IgA important in protecting against Streptococcus pneumoniae

Tetanus - Case report of tetanus in immunized, healthy adult and no point of entry

Tuberculosis - Tuberculosis and HIV co-infection is a symbiotic relationship

Tuberculosis Vaccine - CD8 T cell activation protects against pulmonary tuberculosis

Tuberculosis Vaccine - Guidelines for latent tuberculosis testing and treatment released

Vaccine Adjuvant - Association of antigens to ISCOMATRIX adjuvant improves CTL responses

Vaccine Adjuvant - Cannabinoid is an adjuvant and in vivo chemoattractant for dendritic cells

Vaccine Adjuvant - Vaccines that facilitate antigen entry into dendritic cells reviewed

Vaccine Development - HER-2 Protein AutoVac starts phase II trial in breast cancer

Vaccine Development - Promoters are important elements in the design of DNA vaccines

Vaccine Development - U.S. HHS buys new anthrax vaccine for stockpile

Vaccine Development - Vaccinia vector with antigen-linked calreticulin elicits an antitumor response

Vaccine Development - Vectors expressing hepatitis C virus E1 proteins display antigenicity

Vaccine Safety - Childhood vaccine finance and safety issues reviewed

Vaccinia Virus - Vaccinia virus mutants fail to initiate morphogenesis

Vector Development - Porcine adenoviral vectors are effective vehicles for gene delivery

West Nile Virus - Netherlands Vaccine Institute signs agreement to produce West Nile vaccine

Wilms' Tumor Gene Vaccine - Wilms' tumor gene peptide vaccine causes cancer regression

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