Salmonella Vaccine

Delta yej Salmonella mutants induce superior CD8+ T-cell responses

Published in Vaccine Weekly, December 8th, 2004

Scientists have identified Salmonella typhimurium genes responsible for interfering with peptide presentation on MHC class I molecules.

According to recent research published in the journal Cellular Microbiology, "Salmonella-derived epitopes are presented on MHC molecules by antigen-presenting cells, and both CD4+ and CD8+ T cells participate in protective immunity to Salmonella. Therefore, mechanisms that allow Salmonella to escape specific immune recognition are likely to have evolved in this bacterial pathogen. To identify Salmonella genes, which potentially interfere with the MHC class I (MHC-I) presentation pathway, Tn10d...

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Source: Vaccine Weekly (2004-12-08)

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