Vaccine Adjuvant

Association of antigens to ISCOMATRIX adjuvant improves CTL responses

Published in Vaccine Weekly, December 8th, 2004

Association of antigens to ISCOMATRIX adjuvant using metal chelation leads to improved CTL responses.

"The association of antigen with ISCOMATRIX adjuvant has been shown to be important for the optimal induction of cytotoxic T lymphocyte (CTL) responses. Here, we describe a simple broadly applicable method for associating recombinant proteins with hexa-histidine tags to ISCOMATRIX adjuvant utilizing metal-affinity chelating interactions. The metal chelation binding step can be performed in a wide range of buffers, including commonly used denaturants such as urea, which makes it an ideal strategy for formulating proteins which are otherwise insoluble," researchers in...

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Source: Vaccine Weekly (2004-12-08)

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