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Malaria Vaccine

Immunogenicities of Plasmodium vivax protein fragments compared

Published in Vaccine Weekly, December 8th, 2004

Scientists compare immunogenicities of recombinant Plasmodium vivax merozoite surface protein 1 19- and 42-kilodalton fragments expressed in Escherichia coli in a recent issue of Infection and Immunity.

"The 42- and 19-kDa C-terminal fragments of merozoite surface protein 1 (MSP-142 and MSP-119 , respectively) are both promising blood-stage vaccine candidate antigens. At present, it is not clear which of the two antigens will be more suitable for inclusion in a cocktail malaria vaccine. In the present study, we expressed the two C-terminal fragments of Plasmodium vivax MSP-1 (PvMSP-1) in an Escherichia coli...

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