Published in Vaccine Weekly, December 8th, 2004
"The nontoxic B subunit of Escherichia coli beat-labile enterotoxin (EtxB) is a potent immunomodulatory molecule that acts both as an adjuvant and to stimulate immune deviation processes, resulting in the suppression of Th1-associated inflammatory responses. The ability of EtxB to alter immune reactivity is dependent on its ability to modulate immune cell function through binding to cell surface molecules, the principal receptor of which is the ubiquitous GM1 -ganglioside. EtxB activates B cells and...
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