Allergy Vaccine
Epitope modulation of Bet v 1 reduces IgE binding but retains protein folding
Published in Vaccine Weekly, December 15th, 2004
According to published research from Denmark, "Human type 1 immediate allergic response symptoms are caused by mediator release from basophils and mast cells. This event is triggered by allergens aggregating preformed IgE Abs bound to the high-affinity receptor (FcepsilonRI) on these cells. Thus, the allergen/IgE interaction is crucial for the cascade leading to the allergic and anaphylactic response. Two genetically engineered forms of the white birch pollen major allergen Bet v 1 with point mutations directed at...
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Source: Vaccine Weekly (2004-12-15)
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