AIDS/HIV Pathogenesis
DC-SIGN interference inhibits HIV transmission from dendritic to T cells
Published in Vaccine Weekly, December 22nd, 2004
"In the early events of human immunodeficiency virus type 1 (HIV-1) infection, immature dendritic cells (DCs) expressing the DC-specific intercellular adhesion molecule 3-grabbing nonintegrin (DC-SIGN) receptor capture small amounts of HIV-1 on mucosal surfaces and spread viral infection to CD4+ T cells in lymph nodes (22, 34, 45). RNA interference has emerged as a powerful tool to gain insight into gene function. For this purpose, lentiviral vectors that express short hairpin RNA (shRNA) for the delivery of small interfering RNA...
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Source: Vaccine Weekly (2004-12-22)
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