Filariasis Vaccine

Gender-regulated transcripts in Brugia malayi by real-time PCR analyzed

Published in Vaccine Weekly, December 29th, 2004

Researchers have conducted a quantitative analysis of gender-regulated transcripts in the filarial nematode Brugia malayi by real-time RT-PCR.

According to a study from the United States, "Improved understanding of the biology of reproduction in filarial worms may lead to identification of new targets for drugs or vaccines. Real-time RT-PCR is increasingly being adopted for RNA quantification and genetic analysis. Candidate gender-regulated genes were selected from genes identified in prior studies by differential display RT-PCR and by electronic selection of the Brugia malayi expression sequence tag (EST) database for clusters with possible...

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Source: Vaccine Weekly (2004-12-29)

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