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Vaccine Weekly

Susan Hasty, Publisher

Table of Contents . . . January 5th, 2005

Non-Subscriber - Summaries Only

Related Areas: Other Issues in Vaccine Weekly | Other Publications

AIDS/HIV Vaccine - Lentiviruses limited to single cycle of infection generated

Cancer Vaccine - Antigen choice influences efficacy of antitumor dendritic cell cancer vaccine

Cancer Vaccine - Virosomes used as carrier system for cancer vaccines

Coccidioidomycosis Vaccine - Host response to coccidioidomycosis and vaccine development reviewed

Prostate Cancer - Polyvalent prostate cancer vaccine developed

AIDS/HIV Vaccine - Dendritic cell infection by HIV promotes virus resistant to antibodies

Allergy Medicine - Company initiates a phase II trial with its immunodrug candidate CYT005-AllQbG10

Alzheimer Disease - Gene vaccine for AD shows promising results

Alzheimer Disease - Mimotopes of conformational epitopes in fibrillar beta-amyloid identified

Anthrax - Speedy reaction better than vaccination for beating anthrax

Awards - Harvard Health Publications lists top 10 health stories for 2004

Bacteriology - Cell transmigration induced by Pseudomonas requires hepoxilin A3

Bioterrorism - Defense contractor signs NIH agreement to evaluate virus inactivation method

Brain Cancer - Anticancer vaccine doubles time-to-disease progression, increases survival

Breast Cancer - Data presented from early breast cancer treatment trial

Business & Finance - Biodefense-focused biopharma to submit compliance plan to AMEX

Business Update - Biotechnology company enters Fluviral vaccine marketing, distribution agreements

Business Update - Company reports sale of p38 kinase inflammation inhibitor program to Novartis

Business Update - Diagnostic technology company engages Middle East distribution company

Business Update - Healthcare services company signs distribution, purchasing agreements

Cancer Therapy - Bioproducts companies collaborate to develop, market anticancer drug

Cervical Cancer - Vaccine prevents and treats cervical cancer tumors in mice

Childhood Immunization - Health actions for children in Togo to save thousands of lives in record time

Contraception - Mouse-specific contraceptive vaccines developed

Cytomegalovirus Vaccine - Immune cells protect perforin knockout mice from cytomegalovirus retinitis

Dendritic Cell Vaccine - CD28 induces immunostimulatory signals in dendritic cells via CD80 and CD86

Dendritic Cell Vaccine - Picibanil shows promise as adjuvant for dendritic cell vaccines

Encephalomyelitis - Dendritic cells exposed to estrogen are therapeutic for encephalomyelitis

Gastric Cancer - Gastrin and IL-1beta stimulate growth factor secretion from gastric cells

HIV/AIDS - Massachusetts health leaders convene to evaluate status of AIDS in the state

HIV/AIDS - Vscan HIV 1&2 test kits begin Ukraine approval process

HIV/AIDS Prevention - Global Fund exec praises China's response to HIV/AIDS and TB

HIV/AIDS Therapy - Canadian researchers develop method to assess thymus function

Haemophilus Vaccine -  Haemophilus LPS biosynthesis mechanism similar to that of O-antigen synthesis

Helminth Vaccine - Chronic immune activation associated with helminthic infections reviewed

Hepatitis B Virus - Positive interim results from phase II/III hepatitis B vaccine trial

Herpes - Success of experimental herpes vaccine builds momentum for human clinical trials

Herpesvirus - Toll-like receptor 3 agonist protects against genital herpes

Immunology - Autoreactive B cells negatively selected during memory formation

Immunology - Expression of IL-6-IL-2 fusion protein in Pichia pastoris reported

Immunology - IL-27 receptor inhibits innate and adaptive elements of type 2 immunity

Infectious Disease - Progress and challenges in infectious diseases reviewed

Influenza - Company launches phase III clinical trial for Fluarix

Influenza - Flu shot supply grows, but demand withers

Influenza - HHS purchases 1.2 million doses of flu vaccine

Influenza - Pennsylvania Department of Health confirms first influenza case

Influenza Vaccine - Arizona health officials have surplus of flu vaccine instead of shortage

Influenza Vaccine - Biotechnology company to ship 1.2M doses of flu vaccine to Canadian market

Influenza Vaccine - Flu shots available to Vermont adults 65 years and up and to babies

Influenza Vaccine - Health Department: New Hampshire has enough flu vaccine

Influenza Vaccine - Iowa health officials expand flu vaccine eligibility list

Influenza Vaccine - Kansas expands list of people eligible to receive flu vaccine

Influenza Vaccine - South Carolina Dept. of Health and Environmental Control gets more flu shots

Influenza Vaccine - Steady demand for flu shots in Rhode Island

Influenza Vaccine - Transcriptional analysis of PBMCs after influenza immunization reported

Influenza Vaccine - Vaccine company commented on influenza vaccine supply and distribution

Influenza Vaccine - Washington still has plenty of flu vaccine for high-priority kids

Influenza Virus - German recommendations for antiviral treatment of influenza outlined

Information Technology - $19.7M awarded for development of biodefense vaccines

Leukemia - Peptide vaccine can produce remission in myeloid leukemia patients

Lung Cancer - Immunotherapy vaccine trial of lung cancer treatment results reported

Malaria Vaccine - Serine repeat antigen gene family phylogeny in Plasmodium investigated

Nematode Infection - T helper cell responsiveness predicts susceptibility to nematodes in humans

Non-Hodgkin Lymphoma - Phase 1 data of talabostat in non-Hodgkin lymphoma patients presented

Pain Medicine - Enrollment target reached for opioid-induced constipation trial

Patents - New European patent issued for manufacture of nanoparticles

Personnel - Philippe Archinard named CEO of French cancer-focused biopharmaceutical company

Pneumococcal Vaccine - Azithromycin modulates murine immune responses to pneumococcal vaccine

Pneumococcal Vaccine - Colostrum from pneumococcal-vaccinated women inhibits Streptococcus adhesion

Polio Vaccine - Poliovirus-specific antibody response may promote Bifidobacterium

Proteomics - Polyclonal antibodies used as tool for proteomics research

Pseudomonas Vaccine -  Pseudomonas aeruginosa alginate antibodies protect against infection

Rheumatoid Arthritis - Mutant IL-15/Fc protein prevents development of collagen-induced arthritis

SARS - SARS vaccine primarily proved safe and effective

SARS - U.S. government launching human trials of experimental SARS vaccine

SARS Vaccine - Expression system for release of SARS coronavirus-like particles developed

Staphylococcus Vaccine - Prospective targets for staphylococci drugs and vaccines reviewed

Stock Market - Sinovac Biotech Ltd. begins trading on American Stock Exchange

Tetanus Vaccine - Postsurgical tetanus reviewed

Trichomoniasis - Treatment metronidazole-resistant Trichomonas vaginalis infections reviewed

Tuberculosis Vaccine - New issues in tuberculosis outlined

Tuberculosis Vaccine - Recombinant vaccinia virus boosts antimycobacterial immunity in humans

Typhoid Vaccine - CD8+ T cell subset identified in patients immunized with typhoid vaccine

Vaccine Delivery - Method to deliver micro-particles into skin developed

Vaccine Development -  Staphylococcus aureus polysaccharide conjugate vaccine development update

Vaccine Development - Bovine aortic endothelial cell immunization stalls glioma neovascularization

Vaccine Development - Encapsulated hepatitis B antigen boosts immunogenicity with a single dose

Vaccine Development - Poll indicates need for more vaccine products

Vaccine Development - Vaccination in humans generates broad T cell cytokine responses

Vaccine Schedules - Two-dose regimens improve adolescent hepatitis B vaccination uptake

Vector Development - Dendritic cell-based helper-dependent vectors limit antiviral activity

Vibrio Vaccine - Immune responses of barramundi to Vibrio harveyi bacterin described

Virology - Viral chemokine affects mucosal immunity differently than mammalian chemokine

West Nile Virus - U.S. NIH awards $15.5 million for West Nile virus, dengue vaccines

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