Yersinia Vaccine

LcrV synthesis required to confer immunity against Y. pseudotuberculosis

Published in Vaccine Weekly, January 12th, 2005

LcrV synthesis is altered by DNA adenine methylase overproduction in Yersinia pseudotuberculosis and is required to confer immunity in vaccinated hosts.

"Yersinia pseudotuberculosis mutants that overproduce the DNA adenine methylase (Dam^OP Yersinia) are attenuated, confer robust protective immune responses, and synthesize or secrete several Yersinia outer proteins (Yops) under conditions that are nonpermissive for synthesis and secretion in wild-type strains. To understand the molecular basis of immunity elicited by Dam^OP Yersinia, we investigated the effects of Dam overproduction on the synthesis and localization...

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Source: Vaccine Weekly (2005-01-12)

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