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Brain Cancer Vaccine

Human leukocyte antigen-A24-restricted antitumor cell generated

Published in Vaccine Weekly, January 19th, 2005

Scientists have generated a human leukocyte antigen-A24-restricted antitumor cell with the use of SART-1 peptide and dendritic cells in patients with malignant brain tumors.

According to recent research published in the Journal of Laboratory and Clinical Medicine, "Dendritic cells (DCs) can be the principal initiators of antigen-specific immune responses. In this study, we attempted to generate cytotoxic T-lymphocytes (CTLs) using DCs pulsed with SART-1(254) peptide. Peripheral-blood mononuclear cells (PBMCs) and tumor-infiltrating mononuclear cells (TIMCs) were obtained from 11 patients with brain tumors expressing human leukocyte antigen (HLA)-A24."

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