Gastroenterology

Quantitative changes in gastric mucosal glycoproteins investigated

Published in Vaccine Weekly, January 19th, 2005

Researchers examine the effect of cholinergic agonists and vagal nerve stimulation on gastric mucosal glycoproteins in the rat.

According to a study from Nigeria, "The role of the vagus nerve and cholinergic mechanisms in the control of the rat gastric mucin and protein (PROT) release in vivo was investigated. Under urethane anesthesia (1.25 g/kg), the rats had their gastric lumen perfused with saline. Mucus secretion was measured as a function of adherent mucus on the mucosa surface and the luminal content of sialic acids (SIA), galactose (GAL), pyruvate, and PROT. Electrical stimulation of the vagi significantly increased the levels of mucus (3.23±025 mcg/g...

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Source: Vaccine Weekly (2005-01-19)

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