Inflammatory Bowel Disease

Autoantibodies in inflammatory bowel disease impairs antibiotic activity

Published in Vaccine Weekly, January 19th, 2005

Autoantibodies against the bactericidal/permeability-increasing protein from inflammatory bowel disease patients can impair the antibiotic activity of bactericidal/permeability-increasing protein.

"Bactericidal/permeability-increasing protein (BPI) is an antineutrophil cytoplasmic autoantibody (ANCA) target antigen in inflammatory bowel disease (IBD). The aim of this study was to characterize binding regions of BPI-autoantibodies and to analyze their ability to block the antibiotic effect of BPI. Sera of 24 ulcerative colitis and Crohn disease patients were examined in indirect immunofluorescence, ANCA enzyme-linked immunosorbent assay (ELISA), and by epitope mapping...

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Source: Vaccine Weekly (2005-01-19)

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