Inflammatory Bowel Disease

Dendritic cell subpopulations in inflammatory bowel disease characterized

Published in Vaccine Weekly, January 19th, 2005

Scientists have characterized colonic and mesenteric lymph node dendritic cell subpopulations in a murine adoptive transfer model of inflammatory bowel disease.

"Ulcerative colitis and Crohn disease, collectively termed inflammatory bowel diseases (IBD), are chronic inflammatory diseases of the intestine that afflict more than 4 million people worldwide. Intestinal inflammation is characterized by an abnormal mucosal immune response to normally harmless antigens in the gut flora. In Crohn disease, the pathogenic mucosal immune response is a typical T helper (Th1) type cell response, whereas ulcerative colitis is predominantly associated with a Th2 response," scientists...

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Source: Vaccine Weekly (2005-01-19)

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