Leishmaniasis Vaccine

Analog of human beta-casein fragment effective against Leishmania

Published in Vaccine Weekly, January 19th, 2005

A synthetic analog of human beta-casein fragment (54-59) was effective against Leishmania donovani in hamsters.

According to published research from India, "The characteristic feature of visceral leishmaniasis (VL) is the profound impairment of immune system of the infected host, which contributes significantly to the partial success of antileishmanial chemotherapy. Since in VL, cure is the combinatorial effect of drug and immune status of the host, the rationale approach towards antileishmanial chemotherapy would be to potentiate the immune functioning of the host to extract desired results. Toward this direction several rationally designed analogs of human...

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Source: Vaccine Weekly (2005-01-19)

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