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Pneumonia

Discovery of key protein's shape may lead to better bacterial pneumonia vaccine

Published in Vaccine Weekly, January 19th, 2005

Scientists at St. Jude Children's Research Hospital have discovered that the shape of a protein on the surface of pneumonia bacteria helps these germs invade the human bloodstream.

This finding could help scientists develop a vaccine that is significantly more effective at protecting children against the disease.

The St. Jude researchers determined the shape of a large, paddle-like molecule that Streptococcus pneumoniae bacteria use to latch onto cells lining the throat and lungs. The protein, called CbpA, binds to a molecule on the cell called pIgR, which takes antibodies from the bloodstream on one side of the cell and transports them to the...

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