Tetanus Vaccine

Tetanus vaccination with IL-2 during HAART induces sustained T-cell responses

Published in Vaccine Weekly, January 19th, 2005

Tetanus vaccination with IL-2 during highly active antiretroviral therapy (HAART) induces sustained and pronounced specific CD4 T-cell responses.

"HIV-1 infection results in profound dysfunction of the CD4 T-cell population. Although highly active antiretroviral therapy allows the reconstitution of CD4 T-cell numbers, functional abnormalities remain, including inadequate responses to vaccination. IL-2 increases CD4 T-cell numbers and function," scientists in England report.

"We report the effects of IL-2 given with tetanus vaccination in two patients in a larger immunotherapy study," said Gareth A. D. Hardy and colleagues at Imperial College London....

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Source: Vaccine Weekly (2005-01-19)

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