Vaccine Development
Dendritic cell recruitment may broaden the value of DNA vaccines
Published in Vaccine Weekly, January 19th, 2005
"DNA vaccination is a novel immunization strategy that has great potential for the development of vaccines and immune therapeutics. This strategy has been highly effective in mice, while less immunogenic in nonhuman primates and humans. Enhancing DNA vaccine potency remains a challenge," researchers in the United States report.
"It is likely that APCs, and especially DCs, play a paramount role in the presentation of vaccine antigen to the immune system. A new study reports the synergistic recruitment, expansion, and activation of DCs in vivo in a mouse model through covaccination with...
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Source: Vaccine Weekly (2005-01-19)
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