Published in Vaccine Weekly, January 26th, 2005
Study 1: Recombinant spores of Bacillus subtilis can achieve oral priming of mice.
According to a study from Italy, "Recombinant Bacillus subtilis spores were employed as a vaccine delivery system in a heterologous mucosal priming-parenteral boosting vaccination strategy in the mouse model. BALB/c and C57BL/6 mice were orally immunized with recombinant spores expressing tetanus toxin fragment C (TTFC) fused to the spore outer coat protein CotB, and then subcutaneously boosted with soluble TTFC (without adjuvant). Two weeks after...
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