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Vaccine Weekly

Susan Hasty, Publisher

Table of Contents . . . February 2nd, 2005

Non-Subscriber - Summaries Only

Related Areas: Other Issues in Vaccine Weekly | Other Publications

Anthrax Vaccines - Studies advance knowledge in anthrax vaccines research

Cancer Vaccines - Researchers report details of new studies and findings in the area of cancer vaccines

Dendritic Cell Vaccine - Dendritic cell vaccines may prevent fungal infections

Influenza Vaccines - Replication-deficient influenza A viruses protected mice against infection

Malaria Vaccines - Recent findings illuminate research in malaria vaccines

SARS Vaccine - Antigenic sites on nucleocapsid protein of SARS coronavirus mapped

SARS Vaccines - New findings in the area of SARS vaccines described

Tularemia Vaccine - Transposon-transposase complexes create mutants of Francisella tularensis

West Nile Fever Vaccine - West Nile Virus-like particles induced sterilizing immunity

AIDS/HIV Vaccines - New findings in AIDS/HIV vaccines described

African Horsesickness - African horsesickness virus serotyping conducted

Allergy Medicine - Encephalomyelitis suppression by magnetic field depends on timing

Alzheimer Disease - Adenovirus vectors encoding A-beta and GM-CSF reduces amyloid load in brain

Arthritis - Model of adjuvant-induced chronic arthritis in mice developed

Autoimmune Disease - Antigen-based immuno-intervention in human autoimmune diseases reviewed

Avian Influenza Virus - Avian influenza A virus epidemic in the Netherlands in 2003 described

Bacteriology - Bacterial muramyl dipeptide activates NALP3/cryopyrin inflammasome

Brain Cancer - Researchers' findings advance brain cancer research

Breast Cancer - Gene vaccine protects mice against development of Her2/neu breast cancer

Breast Cancer Vaccine - Vaccine against epidermal growth factor receptor useful for breast cancer

Business & Finance - Biotech company announces financial results

Business Update - Chiron CEO says he is unclear when flu vaccine sales can resume

Cancer Risk Factors - Sustained response to hepatitis B virus therapy may lower liver cancer odds

Cancer Vaccine - IL-2-binding cytokines affect costimulatory properties of leukemia cells

Cancer Vaccine - JNK inhibitor rescues melanoma-specific T cells from cell death

Cancer Vaccine - Link between insulin receptor and epidermal growth factor receptors reviewed

Cancer Vaccine - Vaccine transduced with GM-CSF gene enhances immune response in renal cancer

Cancer Vaccines - Researchers describe findings in cancer vaccines studies

Candidiasis - Peptide inhibits adherence of Candida albicans

Chlamydiosis - Ovine live vaccine protects against Chlamydophila abortus-related abortion

Contraception - Studies add new findings to contraception body of knowledge

Cytomegalovirus - Genetic polymorphisms among cytomegalovirus wild-type strains reported

DNA Vaccine - Method to purify plasmid DNA using aqueous two-phase systems developed

Dengue Fever - Chimpanzee Fab fragments and IgG cross-neutralize dengue viruses

Diabetes Pathogenesis - Findings advance knowledge in diabetes pathogenesis research

Diabetes Therapy - Inhibition of adhesion molecules generates resistance to type 1 diabetes

Disease Outbreak - United Nations confirms two cases of measles in tsunami-hit Sumatra

Drug Development - $2M milestone payment issued for marketing approval of Rotarix

Drug Development - Cancer-focused company establishes clinical advisory board

Drug Development - Fast track status granted for ACAM2000 smallpox vaccine

Drug Development - Researchers develop vaccine candidate for West Nile virus

Dysentery - Anti-CD3 helps modulate immune response in Shigella dysenteriae infection

Escherichia Coli Vaccine - Distribution of adhesins in Shiga toxin-producing E. coli reported

Finance - Infection-focused biotech company announces listing on Halter USX China Index

Foot-and-Mouth Disease - Control of foot-and-mouth disease epidemic in Argentina outlined

Global Health - Gangrene, pneumonia and risk of malaria seen in some tsunami refugee camps

Graft-versus-Host Disease - Company announces top-line results of pivotal trial of orBec

HIV/AIDS Diagnostics - Vscan HIV test kits shown 100% accurate in Hati

HIV/AIDS Prevention - HIV vaccine group announces strategic plan

HIV/AIDS Therapy - Fast track status granted for PA-457, a maturation inhibitor

HIV/AIDS Vaccine - Fc-gammaRI is involved in HIV-1 inhibition by polyclonal IgG

HIV/AIDS Vaccine - Gender differences found in HIV-specific CD8 responses in reproductive tract

HIV/AIDS Vaccine - HIV vaccine development contract extension announced

HIV/AIDS Vaccine - HLA-B has dominant influence in mediating co-evolution of HIV and HLA

HIV/AIDS Vaccine - Neutralization analysis of anti-HIV monoclonal antibodies conducted

HIV/AIDS Vaccine - Outer domain of the gp120 glycoprotein from HIV-1 characterized

HIV/AIDS Vaccine - Plan for the next generation of HIV prevention research outlined

HIV/AIDS Vaccine - Variation in dominant epitope affects neutralization of HIV Tat protein

Herpesvirus - Reports describe recent advances in herpesvirus research

Herpesvirus Vaccine - CD4+ CD25+ T cells regulate CD8+ T-cell responses against herpesvirus type 1

Human Papillomavirus Vaccine - GM-CSF in hydrogel stimulates dendritic cell migration in HPV lesions

Human Papillomavirus Vaccine - Human papillomavirus vaccination programs evaluated

Immunology - 4-1BB and OX40 independently facilitate robust CD8 and CD4 recall responses

Immunology - Adaptive immune responses to soluble proteins shaped by TLR agonists

Immunology - Bystander suppression occurs despite normal clonal expansion of T cells

Immunology - Peptide induces antibodies reacting with thyroglobulin and thyroid peroxidase

Immunology - Researchers publish new studies and findings in the area of immunology

Influenza - Georgia confirms second flu case

Influenza Vaccines - After shortage scare, flu shots still available in Minnesota

Influenza Vaccines - California health officials lift restrictions on flu shots

Influenza Vaccines - Flu vaccine supply in Kentucky keeping pace with demands

Influenza Vaccines - Health officials deciding what to do with leftover vaccine doses

Influenza Vaccines - Influenza vaccination exerts immunomodulating effect in elderly

Influenza Vaccines - Neuraminidase activity assays for monitoring influenza virus described

Influenza Vaccines - New England experiencing a glut of flu shots

Influenza Vaccines - South Dakota doctors say flu shots shouldn't go to waste

Leishmaniasis - Proteins secreted from salivary glands of Leishmania vector identified

Malaria - Evidence found for VAR2CSA involvement in pregnancy-associated malaria

Malaria Vaccine - Malaria parasite-inhibitory antibody epitopes merozoite protein mapped

Malaria Vaccine - Pregnancy-associated malaria vaccines reviewed

Malaria Vaccines - New data illuminates research in malaria vaccines

Malaria Vaccines - Reports add new data to malaria vaccines research

Malaria Vaccines - Research in malaria vaccines provides new insights

Malaria Vaccines - Researchers provide details of new studies and findings in the area of malaria vaccines

Malaria Vaccines - Researchers publish new studies and findings in the area of malaria vaccines

Malaria Vaccines - Researchers report details of new studies and findings in the area of malaria vaccines

Meningitis Vaccine - Distribution of Neisseria serogroups and genotypes reported

Meningitis Vaccines - Studies advance knowledge in meningitis vaccines research

Mergers & Acquisitions - Company acquires Celltrion's interest in facility, revises company's agreements

Metapneumovirus Vaccine - Metapneumovirus lacking G glycoprotein yields promising vaccine candidate

Molecular Biology - Scientists reveal molecular secrets of the malaria parasite

Mucosal Immunization - Oral immunization induces local and distant mucosal immunity in swine

Nicotine Vaccine - Immunization against nicotine alters nicotine distribution

Norwalk-type Virus - Virus sickens 116 people on Royal Caribbean International cruise

Occupational Health - Nurses in Turkey are exposed to bloodborne pathogens through sharps injuries

Personnel - Cancer-focused drug company names Guenter Schirmer, MD, PhD, medical director

Personnel - Former governor James Greenwood assumes presidency of biotechnology association

Pertussis Vaccine - Antigen targeting to CD11b allows in vivo Th1-polarized T-cell priming

Pertussis Vaccine - Polymorphisms of fimbria fim3 gene of Bordetella pertussis isolated

Pneumococcal Vaccine - Global distribution of Streptococcus pneumoniae serotypes reported

Pneumococcal Vaccine - Nasopharyngeal and oropharyngeal sampling optimizes pneumococcal detection

Polio Vaccines - Research in polio vaccines provides new insights

Poliomyelitis - U.N. begins vaccinating 6 million Sudanese children against polio

Poliomyelitis - WHO: Polio cases rose by one-third in 2004

Product Licensing - Corixa licenses novel target for therapeutic development and commercialization

Pseudorabies Vaccine - Two modes of pseudorabies virus neuro-invasion and lethality in mice described

Public Health - Global alliance for vaccines not a model for public-private cooperation

Rabies Vaccine - Increased IL-10 and low IL-6 linked to survival in mice infected by rabies

Receptor Studies - Selective estrogen receptor modulators in desmoid tumors reviewed

Respiratory Syncytial Virus - Bovine respiratory syncytial virus infection affects adhesion of neutrophils

SARS Vaccines - New research in the area of SARS vaccines detailed

Schistosomiasis -  Schistosoma mansoni soluble proteome compared across life-cycle stages

Septicemia -  Streptococcus pneumoniae affects protection of pneumococcal antibodies

Smallpox Vaccine - Vaccinia virus infection transmitted through sexual contact with vaccinee

Streptococcus Vaccine - Prevention of neonatal group B streptococcal disease reviewed

Tuberculosis Vaccine - Intranasal BCG dosage needs balancing between protection and lung pathology

Vaccinations - Mass measles vaccinations given in Indonesian tsunami zone

Vaccine Adjuvant - Adjuvant based on proteoliposome-derived cochleate structure developed

Vaccine Adjuvant - Challenges facing adjuvants for cancer immunotherapy reviewed

Vaccine Adjuvant - Cytokines as adjuvants for avian vaccines reviewed

Vaccine Delivery - Monodisperse chitosan nanoparticles used for mucosal drug delivery

Vaccine Development - Biopharma company announced initiation of StaphVAX trial

Vaccine Development - Blocked phosphatidylserine recognition heightens tumor cell immunogenicity

Vaccine Development - Immunization site stipulates the efficacy of tumor immunotherapy

Vaccine Development - Research and development of new vaccines against infectious diseases reviewed

Vaccine Efficacy - Vaccines for women age 50 and older outlined

Vaccine Safety - Global perspective on vaccine safety and public health presented

Vaccine Safety - Immunization in children with chronic renal failure outlined

Varicella Virus - Self-reported history of varicella infection predictive of immunity in adults

Vector Development - Bacmid to improve integrity of secreted recombinant proteins developed

Viral Hemorrhagic Disease - Viral hemorrhagic disease vaccine decreases mortality in wild rabbits

Virology - Studies add new findings to virology body of knowledge

Virology Vaccine - Respiratory syncytial virus and parainfluenza virus vaccines evaluated

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