Vaccine Development
Blocked phosphatidylserine recognition heightens tumor cell immunogenicity
Published in Vaccine Weekly, February 2nd, 2005
"Strategies to enhance the immunogenicity of tumors are urgently needed. Although vaccination with irradiated dying lymphoma cells recruits a tumor-specific immune response, its efficiency as immunogen is poor. Annexin V (AxV) binds with high affinity to phosphatidylserine on the surface of apoptotic and necrotic cells and thereby impairs their uptake by macrophages," researchers in Italy report.
"Here, we report that AxV preferentially targets irradiated lymphoma cells to CD8+ dendritic cells for in vivo clearance, elicits the release of proinflammatory cytokines and...
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Source: Vaccine Weekly (2005-02-02)
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