Nicotine Vaccine
Immunization against nicotine alters nicotine distribution
Published in Vaccine Weekly, February 2nd, 2005
According to published research from Sweden, "We have previously shown that active immunization with the nicotine immunoconjugate IP18-KLH attenuates the reinforcing effects of nicotine, i.e., suppresses the nicotine-induced brain dopamine release and prevents reinstatement of the nicotine-seeking behavior in rats. These effects are thought to be due to an alteration of the kinetics of nicotine distribution by the antibodies, resulting in an attenuated nicotine distribution to the brain. In this study, the distribution of nicotine administered at doses...
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Source: Vaccine Weekly (2005-02-02)
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