Pertussis Vaccine

Polymorphisms of fimbria fim3 gene of Bordetella pertussis isolated

Published in Vaccine Weekly, February 2nd, 2005

Researchers describe polymorphisms of the fimbria fim3 gene of Bordetella pertussis strains isolated in Canada in a recent issue of the Journal of Clinical Microbiology.

According to a study from Canada, "The fim genes which code for the fimbria protective antigens present in both the inactivated whole-cell and acellular vaccines were analyzed in 86 Canadian Bordetella pertussis isolates. "

"At least one of the novel mutations identified was found to involve a surface epitope that has been mapped by serum antibodies from infected or vaccinated subjects," wrote Raymond S. W. Tsang at Health Canada and collaborators in...

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Source: Vaccine Weekly (2005-02-02)

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